Search results for " fractional anisotropy"

showing 3 items of 3 documents

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

2015

Infratentorial lesions have been assigned an equivalent weighting to supratentorial plaques in the new McDonald criteria for diagnosing multiple sclerosis. Moreover, their presence has been shown to have prognostic value for disability. However, their spatial distribution and impact on network damage is not well understood. As a preliminary step in this study, we mapped the overall infratentorial lesion pattern in relapsing–remitting multiple sclerosis patients (N = 317) using MRI, finding the pons (lesion density, 14.25/cm3) and peduncles (13.38/cm3) to be predilection sites for infratentorial lesions. Based on these results, 118 fiber bundles from 15 healthy controls and a subgroup of 23 …

AdultPathologymedicine.medical_specialtyWallerian degenerationCognitive Neurosciencelcsh:Computer applications to medicine. Medical informaticsArticlelcsh:RC346-429LesionWhite matterMultiple sclerosisMultiple Sclerosis Relapsing-RemittingNerve FibersLSAF left superior arcuate fasciculusFractional anisotropymedicineHumansRadiology Nuclear Medicine and imagingFA fractional anisotropyNAWM normal-appearing white matterLD lesion densitylcsh:Neurology. Diseases of the nervous systemEAE experimental autoimmune encephalomyelitisMD mean diffusivitybusiness.industryMultiple sclerosisWhite matterMcDonald criteriaMiddle Agedmedicine.diseaseRD radial diffusivitymedicine.anatomical_structureDiffusion tensor imagingNeurologylcsh:R858-859.7Neurology (clinical)Brainstemmedicine.symptomFunction and Dysfunction of the Nervous SystembusinessBrainstemAD axial diffusivityDiffusion MRIBrain StemICP inferior cerebellar peduncleFractional anisotropyNeuroImage: Clinical
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Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis

2014

Objective White matter atrophy occurs independently of lesions in multiple sclerosis. In contrast to lesion detection, the quantitative assessment of white matter atrophy in individual patients has been regarded as a major challenge. We therefore tested the hypothesis that white matter atrophy (WMA) is present at the very beginning of multiple sclerosis (MS) and in virtually each individual patient. To find a new sensitive and robust marker for WMA we investigated the relationship between cortical surface area, white matter volume (WMV), and whole-brain-surface-averaged rectified cortical extrinsic curvature. Based on geometrical considerations we hypothesized that cortical curvature increa…

MalePathologyROI region of interestFOV field of viewlcsh:RC346-429ImagingGRAPPA generalized autocalibrating partially parallel acquisitionCortex (anatomy)Image Processing Computer-AssistedFA fractional anisotropyWMV white matter volumeTE echo timeCerebral Cortexmedicine.diagnostic_testEVAL Münster Neuroimaging Evaluation SystemMiddle AgedMagnetic Resonance ImagingWhite MatterTR repetition timemedicine.anatomical_structureNeurologyGMV gray matter volumeCerebral cortexCortexlcsh:R858-859.7FemaleAlzheimer's diseasePsychologyCIS clinically isolated syndromeMRITSE turbo spin-echoAdultmedicine.medical_specialtyAdolescentCognitive NeuroscienceCortical curvatureICV intracranial volumelcsh:Computer applications to medicine. Medical informaticsCurvatureArticleEDSS Expanded Disability Status ScaleMultiple sclerosisWhite matterYoung AdultAtrophyAlzheimer DiseasemedicineHumansRadiology Nuclear Medicine and imagingWM white matterlcsh:Neurology. Diseases of the nervous systemAgedMultiple sclerosis3D three-dimensionaleWMV estimated white matter volumeMagnetic resonance imagingmedicine.diseaseΔWMV WMV − eWMVCI confidence intervalCase-Control StudiesGM gray matterAnisotropyDTI diffusion tensor imagingNeurology (clinical)AtrophySD standard deviationDemyelinating DiseasesNeuroImage: Clinical
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Physical activity, aerobic fitness, and brain white matter : Their role for executive functions in adolescence

2020

Highlights • Aerobic fitness level, but not physical activity, is related to white matter properties in the brain. • The relation between physical activity and working memory is moderated by fractional anisotropy (FA) of the corpus callosum. • The FA of the corpus callosum and superior corona radiata moderates the relation between aerobic fitness and working memory.

Malephysical activitySpatial memoryDevelopmental psychologyExecutive functionsExecutive Function0302 clinical medicinenuoretCOGNITIVE CONTROLDWI diffusion-weighted imagingFitnessdiffuusiotensorikuvaus315 Sport and fitness sciencesPLASTICITYFA fractional anisotropyChildOriginal ResearchTBSS Tract-Based Spatial Statisticslcsh:QP351-495White matterCognitionExecutive functionsdiffusion tensor imagingexecutive functionsmurrosikäRD radial diffusivityINTEGRITYfitnessfyysinen kuntomedicine.anatomical_structureDiffusion tensor imagingFemalePsychologyaivotRVP rapid visual information processingwhite matterNeurovetenskaperAD axial diffusivityfractional anisotropyfyysinen aktiivisuusMulti-stage fitness testendocrine systemtoiminnanohjaus (psykologia)AdolescentDISTORTION CORRECTIONMVPA moderate-to-vigorous intensity physical activityPhysical activityTFCE threshold-free cluster enhancementWhite matter03 medical and health sciencesWORKING-MEMORY030225 pediatricsmedicineAerobic exerciseHumansExerciseAgedOBJECTIVE MEASURESMD mean diffusivityWorking memoryPhysical activityNeurosciencesPUBERTAL CHANGESvalkea aineCORPUS-CALLOSUMlcsh:Neurophysiology and neuropsychologySWM patial working memoryVOLUMEMICROSTRUCTURECANTAB Cambridge Neuropsychological Automated Test BatteryMRI magnetic resonance imaging030217 neurology & neurosurgeryFractional anisotropy
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